SS31
A mitochondria-targeted tetrapeptide studied for its affinity to cardiolipin on the inner mitochondrial membrane. Research investigates its role in stabilizing mitochondrial function, reducing reactive oxygen species, and preserving ATP production in models of age-related mitochondrial decline, cardiovascular stress, and neurodegeneration.
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Mechanism of Action
SS-31 (D-Arg-Dmt-Lys-Phe-NH2) is a mitochondria-targeted tetrapeptide that selectively binds cardiolipin on the inner mitochondrial membrane via electrostatic interactions. It stabilizes cristae architecture, reduces cardiolipin peroxidation, and preserves electron transport chain function. Unlike conventional antioxidants, it concentrates in mitochondria independent of membrane potential.
Research References
Full research page →Chavez JD et al. Mitochondrial protein interaction landscape of SS-31. PNAS. 2020. PMID: 32554501
Birk AV et al. The mitochondrial-targeted compound SS-31 re-energizes ischemic mitochondria by interacting with cardiolipin. J Am Soc Nephrol. 2013. PMID: 23846690
Szeto HH. First-in-class cardiolipin-protective compound as a therapeutic agent to restore mitochondrial bioenergetics. Br J Pharmacol. 2014
Mitchell W et al. The mitochondria-targeted peptide SS-31 binds lipid bilayers and modulates surface electrostatics. 2020. PMID: 32273339
Batch History & Certificates of Analysis
Full Batch Record
Active Batches
2S10-2026-001
Received Apr 15, 2026
Qty Received
20 units
No test results on record for this batch.
For Research Use Only. This product is supplied exclusively for in vitro research, laboratory study, and experimental purposes. It is not a drug, supplement, food, or cosmetic, and is not intended for human or veterinary use. See our Compliance & RUO Policy.