MOTS-c
A mitochondrial-derived peptide encoded within the 12S rRNA gene. Studies explore its signaling role in metabolic regulation, insulin sensitivity, and exercise-mimetic pathways. Research interest spans age-related metabolic decline, muscle homeostasis, and cellular stress response.
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Mechanism of Action
MOTS-c (Mitochondrial ORF of the 12S rRNA-c) is a 16-amino-acid peptide encoded within mitochondrial DNA. Under metabolic stress, it translocates to the nucleus in an AMPK-dependent manner and regulates stress-adaptation gene expression. It acts primarily through the Folate-AICAR-AMPK pathway, influencing glucose metabolism, GLUT4 translocation, and fatty acid oxidation.
Research References
Full research page →Lee C et al. The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance. Cell Metab. 2015. PMID: 25738459
Kim SJ et al. The Mitochondrial-Encoded Peptide MOTS-c Translocates to the Nucleus to Regulate Nuclear Gene Expression in Response to Metabolic Stress. Cell Metab. 2018. PMID: 29983246
Yu WD et al. The mitochondrial-derived peptide MOTS-c promotes homeostasis in aged human placenta-derived mesenchymal stem cells in vitro. Mitochondrion. 2021. PMID: 33639272
Merry TL et al. MOTS-c, the Most Recent Mitochondrial Derived Peptide in Human Aging and Age-Related Diseases. 2022. PMID: 36233287
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Batch History & Certificates of Analysis
Full Batch Record
Active Batches
MS10-2026-001
Received Apr 15, 2026
Qty Received
30 units
No test results on record for this batch.
For Research Use Only. This product is supplied exclusively for in vitro research, laboratory study, and experimental purposes. It is not a drug, supplement, food, or cosmetic, and is not intended for human or veterinary use. See our Compliance & RUO Policy.