NAD+
A coenzyme central to redox reactions and sirtuin activation. Research examines its involvement in DNA repair pathways (PARP activity), mitochondrial biogenesis, and age-associated NAD decline. Studies investigate relationships to cellular senescence, metabolic health, and neuroprotection.
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Mechanism of Action
NAD+ functions as an obligate cofactor for sirtuins (SIRT1-7), PARPs (DNA repair), and CD38. It is central to redox reactions in glycolysis, the TCA cycle, and oxidative phosphorylation. Cellular NAD+ declines with age; research investigates restoration via precursors like NR and NMN as a lever for sirtuin-mediated longevity pathways and DNA repair capacity.
Research References
Full research page →Imai S, Guarente L. NAD+ and sirtuins in aging and disease. Trends Cell Biol. 2014. PMID: 24786309
Martens CR et al. Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults. Nat Commun. 2018
Rajman L et al. Therapeutic potential of NAD-boosting molecules: the in vivo evidence. Cell Metab. 2018
Kane AE, Sinclair DA. Sirtuins and NAD+ in the Development and Treatment of Metabolic and Cardiovascular Diseases. Circ Res. 2018
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Batch History & Certificates of Analysis
Full Batch Record
Active Batches
NJ500-2026-001
Received Apr 15, 2026
Qty Received
30 units
No test results on record for this batch.
For Research Use Only. This product is supplied exclusively for in vitro research, laboratory study, and experimental purposes. It is not a drug, supplement, food, or cosmetic, and is not intended for human or veterinary use. See our Compliance & RUO Policy.