Epithalon
A synthetic tetrapeptide (Ala-Glu-Asp-Gly) studied for telomerase activity and telomere length modulation. Research areas include circadian rhythm regulation via pineal gland signaling, melatonin production, and markers of biological aging in experimental models.
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Mechanism of Action
Epithalon (Ala-Glu-Asp-Gly) is a synthetic tetrapeptide modeled on the bovine pineal gland extract epithalamin. Research indicates it binds specific DNA sequences and upregulates telomerase reverse transcriptase expression. It also appears to modulate melatonin synthesis via pineal gland signaling, with downstream effects on circadian-regulated gene expression and pineal-related biomarkers.
Research References
Full research page →Khavinson VK et al. Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells. Bull Exp Biol Med. 2003. PMID: 12937682
Al-Dulaimi S et al. Epitalon increases telomere length in human cell lines through telomerase upregulation or ALT activity. Biogerontology. 2025. PMID: 40908429
Araj SK et al. Overview of Epitalon—Highly Bioactive Pineal Tetrapeptide with Promising Properties. Int J Mol Sci. 2025. PMID: 40141333
Anisimov VN et al. Effect of Epitalon on biomarkers of aging, life span and spontaneous tumor incidence in female Swiss-derived SHR mice. Biogerontology. 2003
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Batch History & Certificates of Analysis
Full Batch Record
Active Batches
ET10-2026-001
Received Apr 15, 2026
Qty Received
10 units
No test results on record for this batch.
For Research Use Only. This product is supplied exclusively for in vitro research, laboratory study, and experimental purposes. It is not a drug, supplement, food, or cosmetic, and is not intended for human or veterinary use. See our Compliance & RUO Policy.