Semax
A synthetic heptapeptide derived from a fragment of adrenocorticotropic hormone (ACTH 4-10). Research explores its nootropic properties, BDNF and NGF modulation, neuroprotection in ischemic models, and effects on attention and memory tasks.
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Mechanism of Action
Semax (Met-Glu-His-Phe-Pro-Gly-Pro) is a synthetic heptapeptide analog of ACTH fragment 4-10, with a C-terminal Pro-Gly-Pro sequence that resists enzymatic degradation. Research shows intranasal administration increases BDNF protein levels and trkB phosphorylation in rat hippocampus, with a 3-fold increase in BDNF mRNA. It modulates dopaminergic and serotonergic systems and may interact with melanocortin receptors (MC4/MC5) as antagonist or partial agonist. Approved in Russia for ischemic stroke.
Research References
Full research page →Dolotov OV et al. Semax, an analog of ACTH(4-10) with cognitive effects, regulates BDNF and trkB expression in the rat hippocampus. Brain Res. 2006. PMID: 16996037
Dolotov OV et al. Semax, an analogue of adrenocorticotropin (4-10), binds specifically and increases levels of brain-derived neurotrophic factor protein in rat basal forebrain. J Neurochem. 2006. PMID: 16635254
Shadrina MI et al. The heptapeptide SEMAX stimulates BDNF expression in different areas of the rat brain in vivo. PMID: 14556513
Medvedeva EV et al. The peptide semax affects the expression of genes related to the immune and vascular systems in rat brain focal ischemia. BMC Genomics. 2014
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For Research Use Only. This product is supplied exclusively for in vitro research, laboratory study, and experimental purposes. It is not a drug, supplement, food, or cosmetic, and is not intended for human or veterinary use. See our Compliance & RUO Policy.