Selank
A synthetic heptapeptide analog of tuftsin. Research focuses on anxiolytic properties without sedation, GABAergic modulation, immune system interaction, and effects on stress-response pathways.
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Mechanism of Action
Selank (Thr-Lys-Pro-Arg-Pro-Gly-Pro) is a synthetic heptapeptide analog of the immunomodulatory peptide tuftsin, with an added Pro-Gly-Pro C-terminal for metabolic stability. Clinical studies in Russia show anxiolytic activity comparable to benzodiazepines without sedation, tolerance, or withdrawal. Research indicates modulation of GABAergic and serotonergic systems, influence on enkephalin metabolism, and rapid elevation of BDNF in the rat hippocampus.
Research References
Full research page →Kozlovskaya MM et al. Selank and short peptides of the tuftsin family in the regulation of adaptive behavior in stress. Neurosci Behav Physiol. 2003. PMID: 14969422
Volkova A et al. Selank Administration Affects the Expression of Some Genes Involved in GABAergic Neurotransmission. Front Pharmacol. 2016. PMID: 26973530
Zozulya AA et al. Efficacy and possible mechanisms of action of a new peptide anxiolytic selank in the therapy of generalized anxiety disorders and neurasthenia. 2008. PMID: 18454096
Kolik LG et al. Selank, Peptide Analogue of Tuftsin, Protects Against Ethanol-Induced Memory Impairment by Regulating of BDNF Content. Bull Exp Biol Med. 2019
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For Research Use Only. This product is supplied exclusively for in vitro research, laboratory study, and experimental purposes. It is not a drug, supplement, food, or cosmetic, and is not intended for human or veterinary use. See our Compliance & RUO Policy.