Kisspeptin
A neuropeptide central to the hypothalamic-pituitary-gonadal axis. Research investigates its regulatory role in GnRH secretion, puberty onset, reproductive function, and fertility in both male and female models.
Unit Price
Sign in to view pricing.
Purchase requires a verified researcher account and a signed RUO attestation.
All batch test results and certificates of analysis are published below — including any batches that failed testing. Full transparency is our standard.
Mechanism of Action
Kisspeptin is the endogenous ligand for the KISS1R (GPR54) receptor and a master regulator of the hypothalamic-pituitary-gonadal (HPG) axis. It acts upstream of GnRH neurons, triggering pulsatile GnRH release, which in turn drives LH and (less potently) FSH secretion. Loss-of-function mutations in KISS1R cause hypogonadotropic hypogonadism. Kisspeptin stimulates LH release 2-3-fold in humans in most contexts.
Research References
Full research page →Seminara SB et al. The GPR54 gene as a regulator of puberty. N Engl J Med. 2003
Dhillo WS et al. Kisspeptin-54 stimulates the hypothalamic-pituitary gonadal axis in human males. J Clin Endocrinol Metab. 2005. PMID: 16174713
Skorupskaite K et al. The kisspeptin-GnRH pathway in human reproductive health and disease. Hum Reprod Update. 2014. PMID: 24615662
Hu KL et al. The Role of Kisspeptin in the Control of the Hypothalamic-Pituitary-Gonadal Axis and Reproduction. Front Endocrinol. 2022. PMID: 35837314
Related Products
Batch History & Certificates of Analysis
Full Batch Record
No batch records available for this product yet.
For Research Use Only. This product is supplied exclusively for in vitro research, laboratory study, and experimental purposes. It is not a drug, supplement, food, or cosmetic, and is not intended for human or veterinary use. See our Compliance & RUO Policy.