PMID: 16996037
Peptide Research
Semax
SKU: XA10
Semax (Met-Glu-His-Phe-Pro-Gly-Pro) is a synthetic heptapeptide analog of ACTH fragment 4-10, with a C-terminal Pro-Gly-Pro sequence that resists enzymatic degradation. Research shows intranasal administration increases BDNF protein levels and trkB phosphorylation in rat hippocam…
View Catalog →For Research Use Only
Mechanism of Action
Semax (Met-Glu-His-Phe-Pro-Gly-Pro) is a synthetic heptapeptide analog of ACTH fragment 4-10, with a C-terminal Pro-Gly-Pro sequence that resists enzymatic degradation. Research shows intranasal administration increases BDNF protein levels and trkB phosphorylation in rat hippocampus, with a 3-fold increase in BDNF mRNA. It modulates dopaminergic and serotonergic systems and may interact with melanocortin receptors (MC4/MC5) as antagonist or partial agonist. Approved in Russia for ischemic stroke.
Research Studies
3 peer-reviewed studies curated for Semax.
Other — 3
PMID: 16635254
Dolotov OV et al. Semax, an analogue of adrenocorticotropin (4-10), binds specifically and increases levels of brain-derived neurotrophic factor protein in rat basal forebrain. J Neurochem. 2006
View on PubMed →PMID: 14556513
Shadrina MI et al. The heptapeptide SEMAX stimulates BDNF expression in different areas of the rat brain in vivo
View on PubMed →Related Research
Primary cognition-focused peptide in the catalog. Often studied alongside Selank (complementary CNS modulation via different mechanism). Researchers interested in neuroprotection pair it with SS-31 (mitochondrial neuroprotection) and NAD+ (neuronal bioenergetics).