PMID: 14999221
Peptide Research
PT-141
SKU: PT41
PT-141 (Bremelanotide) is a synthetic cyclic heptapeptide analog of alpha-melanocyte-stimulating hormone. It acts as a non-selective melanocortin receptor agonist, with primary research interest at MC3R and MC4R in the hypothalamus. Unlike PDE5 inhibitors acting on vascular smoot…
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Mechanism of Action
PT-141 (Bremelanotide) is a synthetic cyclic heptapeptide analog of alpha-melanocyte-stimulating hormone. It acts as a non-selective melanocortin receptor agonist, with primary research interest at MC3R and MC4R in the hypothalamus. Unlike PDE5 inhibitors acting on vascular smooth muscle, its mechanism operates through CNS pathways. FDA-approved in 2019 (Vyleesi) for hypoactive sexual desire disorder in premenopausal women; dual mechanism involves nitric oxide release and central arousal modulation.
Research Studies
2 peer-reviewed studies curated for PT-141.
Related Research
CNS-mediated mechanism unique within the catalog. Occasionally studied alongside Kisspeptin for complementary reproductive axis research (different mechanisms converging on sexual function), and with Selank where stress-response interactions are examined.