PMID: 16174713
Peptide Research
Kisspeptin
SKU: KS10
Kisspeptin is the endogenous ligand for the KISS1R (GPR54) receptor and a master regulator of the hypothalamic-pituitary-gonadal (HPG) axis. It acts upstream of GnRH neurons, triggering pulsatile GnRH release, which in turn drives LH and (less potently) FSH secretion. Loss-of-fun…
View Catalog →For Research Use Only
Mechanism of Action
Kisspeptin is the endogenous ligand for the KISS1R (GPR54) receptor and a master regulator of the hypothalamic-pituitary-gonadal (HPG) axis. It acts upstream of GnRH neurons, triggering pulsatile GnRH release, which in turn drives LH and (less potently) FSH secretion. Loss-of-function mutations in KISS1R cause hypogonadotropic hypogonadism. Kisspeptin stimulates LH release 2-3-fold in humans in most contexts.
Research Studies
3 peer-reviewed studies curated for Kisspeptin.
Other — 3
PMID: 24615662
Skorupskaite K et al. The kisspeptin-GnRH pathway in human reproductive health and disease. Hum Reprod Update. 2014
View on PubMed →PMID: 35837314
Hu KL et al. The Role of Kisspeptin in the Control of the Hypothalamic-Pituitary-Gonadal Axis and Reproduction. Front Endocrinol. 2022
View on PubMed →Related Research
Unique mechanism within the catalog; occasionally studied alongside PT-141 for complementary reproductive and CNS-mediated pathway research, and with CJC-1295 + Ipamorelin for broader neuroendocrine axis studies.