PMID: 12937682
Peptide Research
Epithalon
SKU: ET10
Epithalon (Ala-Glu-Asp-Gly) is a synthetic tetrapeptide modeled on the bovine pineal gland extract epithalamin. Research indicates it binds specific DNA sequences and upregulates telomerase reverse transcriptase expression. It also appears to modulate melatonin synthesis via pine…
View Catalog →For Research Use Only
Mechanism of Action
Epithalon (Ala-Glu-Asp-Gly) is a synthetic tetrapeptide modeled on the bovine pineal gland extract epithalamin. Research indicates it binds specific DNA sequences and upregulates telomerase reverse transcriptase expression. It also appears to modulate melatonin synthesis via pineal gland signaling, with downstream effects on circadian-regulated gene expression and pineal-related biomarkers.
Research Studies
3 peer-reviewed studies curated for Epithalon.
Other — 3
PMID: 40908429
Al-Dulaimi S et al. Epitalon increases telomere length in human cell lines through telomerase upregulation or ALT activity. Biogerontology. 2025
View on PubMed →PMID: 40141333
Araj SK et al. Overview of Epitalon—Highly Bioactive Pineal Tetrapeptide with Promising Properties. Int J Mol Sci. 2025
View on PubMed →Related Research
Core component of longevity-focused research protocols. Commonly paired with NAD+ (sirtuin pathway overlap), SS-31 (mitochondrial aging), MOTS-c (metabolic aging pathways), and Glutathione (oxidative stress component of cellular senescence).