Tesamorelin
A growth hormone-releasing hormone (GHRH) analog. Research focuses on visceral adipose tissue reduction, IGF-1 axis modulation, and lipid metabolism, particularly in studies involving HIV-associated lipodystrophy and age-related body composition changes.
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Mechanism of Action
Tesamorelin is a 44-amino-acid stabilized analog of GHRH with a trans-3-hexenoic acid modification that resists DPP-IV degradation. It binds GHRH receptors on anterior pituitary somatotrophs, stimulating pulsatile GH release, which in turn elevates hepatic IGF-1. Clinical trials demonstrated preferential reduction of visceral adipose tissue (approximately 15-20% VAT reduction over 26 weeks) with minimal effect on subcutaneous fat. FDA-approved for HIV-associated lipodystrophy.
Research References
Full research page →Falutz J et al. Metabolic Effects of a Growth Hormone-Releasing Factor in Patients with HIV. N Engl J Med. 2007. PMID: 18057338
Falutz J et al. Effects of tesamorelin (TH9507), a growth hormone-releasing factor analog, in HIV-infected patients with excess abdominal fat: a pooled analysis of two phase 3 trials. J Clin Endocrinol Metab. 2010. PMID: 20554713
Adrian S et al. The Growth Hormone Releasing Hormone Analogue, Tesamorelin, Decreases Muscle Fat and Increases Muscle Area in Adults with HIV. J Frailty Aging. 2019. PMID: 31237318
Stanley TL et al. Effects of tesamorelin on visceral fat and liver fat in HIV-infected patients. JAMA. 2014
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For Research Use Only. This product is supplied exclusively for in vitro research, laboratory study, and experimental purposes. It is not a drug, supplement, food, or cosmetic, and is not intended for human or veterinary use. See our Compliance & RUO Policy.